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نارسایی چندعضوی
Multiorgan Failure
With the advent of vigorous fluid resuscitation, irreversible burn shock has been replaced by sepsis and subsequent multiorgan failure as the leading cause of death associated with burns.
In our pediatric burn population with burns of more than 80% TBSA, sepsis defined by bacteremia developed in 17.5% of the children.11 fte mortality rate in the whole group was 33%; most of these deaths were attributable to multiorgan failure.
Some of the patients who died were bacteremic and "septic," but most were not. ftese findings highlight the observation that develop- ment of multiorgan failure is often associated with infectious sepsis, but infection is by no means required for development of multiorgan failure.
It has been postulated that the progression to multiorgan failure exists in a continuum with the systemic inflammatory response syndrome.
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